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In rare cases, abnormal receptors on the adrenal glands can cause excess cortisol and Cushing’s syndrome, according to a case report. Identifying these receptors can allow physicians to treat the disease pharmacologically rather than surgically, the researchers say. The report, “Two cases of Cushing’s syndrome due to primary…

Local treatment of eye inflammation with steroid medication may cause Cushing’s syndrome and adrenal insufficiency in babies, according to a small study from Denmark. The study, “Adrenal Suppression in Infants Treated with Topical Ocular Glucocorticoids,” published in the journal Ophthalmology, recommends that such treatments, when necessary,…

Measuring the variation in thyroid stimulating hormone blood levels between midnight and morning may be better for diagnosing Cushing’s syndrome than current approaches, a study suggests.  The study, “TSH ratio as a novel diagnostic method for Cushing’s syndrome,” was published in the Endocrine…

Patients with a form of Cushing’s syndrome caused by a tumor outside the pituitary gland that produces excess adrenocorticotropic hormone (ACTH) could be classified into two subgroups, researchers suggest in a recent study. These subgroups are divided by clinical and biochemical characteristics — mostly by type and stage of the…

A study examining the genes expressed in pituitary tumors of Cushing’s disease patients found that these tumors may be grouped into three distinct subsets. The finding suggests that different biological processes contribute to the development of each subset, an insight that may aid in developing targeted therapies. The study, “…

Cushing’s syndrome patients who have adrenal insufficiency have increased risk of death due to disease-related complications, rather than adrenal crisis or adverse occurrences, an observational study suggests. The study, “Mortality data from the European Adrenal Insufficiency Registry—Patient characterization and associations,” was published in the journal Clinical…

Researchers have reported the case of a person who developed Cushing’s syndrome due to a tumor in the thymus, which was successfully managed with surgical removal and radiation therapy. The case report, “Cushing’s syndrome caused by ACTH-producing thymic typical carcinoid with local invasion and regional lymph node metastasis: a…

Cushing’s disease patients who exhibit nodules or masses in their lungs should be thoroughly investigated to exclude fungal infection with Cryptococcus neoformans, a study from China suggests. While rare, the infection can be life-threatening, showing a particularly worse prognosis in patients with fluid infiltration in their lungs or with low white blood…

Cushing’s syndrome patients diagnosed earlier in the disease’s course are more likely to have better mental health and health-related quality of life in the long term, a study reports. The study, “Surviving ectopic Cushing’s syndrome: Quality of life, cardiovascular and metabolic outcomes in comparison to Cushing’s disease during long-term…

MEKT1, a type of therapy called a PPAR-γ agonist, acts to reduce levels of the adrenocorticotropic hormone and could be a potential new therapy for Cushing’s disease, according to researchers. Their study, “Inhibitory Effects of a Novel PPAR-γ Agonist MEKT1 on Pomc Expression/ACTH Secretion in AtT20…