News

Isturisa found to be safe, effective in long-term trial extension

Long-term treatment with Isturisa (osilodrostat) led to a sustained normalization in cortisol levels, symptom relief, and improved quality of life for people with Cushing’s disease, according to the full results from the LINC 4 clinical trial and its extension phase. “These data provide further evidence of the durable clinical…

First patient enters extension study of SPI-62

The first patient has opted to enter the open-label extension study of a Phase 2 trial testing SPI-62 in people with adrenocorticotropic hormone (ACTH)-dependent forms of Cushing’s syndrome, including Cushing’s disease. The announcement was made by SPI-62’s developer, Sparrow Pharmaceuticals, which is conducting a Phase 2 trial called…

Cushing’s syndrome seen in newborn with rare genetic disorder

A newborn girl with a rare genetic disorder called McCune-Albright syndrome (MAS) developed Cushing’s syndrome, according to researchers in Turkey. While Cushing’s syndrome in the context of MAS is linked to a poor prognosis, no specific guidelines exist for diagnosing and treating these rare cases. The newborn’s condition improved following…

People with Cushing’s show ‘paradoxical’ immune profile: Study

People with Cushing’s syndrome, including those with Cushing’s disease, exhibit immune system alterations that could contribute to some symptoms of the disease, a small study suggests. Analyses of immune cells from Cushing’s patients indicated signs of both systemic (whole body) inflammation as well as immunosuppression, which scientists believe might…

Rare adrenal tumor found as cause of woman’s Cushing’s syndrome

A woman who developed Cushing’s syndrome caused by an adenoma — a benign tumor in the adrenal gland — saw her symptoms ease after she had surgery to remove the gland, scientists in Nepal reported. In rare cases, adrenal adenomas are associated with high levels of metanephrine, a byproduct of…