News

A Phase 4 clinical trial will assess the prevalence of excessive cortisol, or hypercortisolism, in people with difficult-to-treat type 2 diabetes, and the effectiveness of Korlym (mifepristone) in lowering cortisol levels, Corcept Therapeutics announced. The two-part, placebo-controlled CATALYST (NCT05772169) study is expected to enroll up to…

Participants are poised for Cushing’s Awareness Day, observed every April 8, to call attention to Cushing’s disease, a disorder that causes a host of physical, mental, and hormonal issues. The day also marks the birthday of Harvey Cushing, widely considered the father of neurosurgery, who first described Cushing’s disease…

A 28-year-old pregnant woman was diagnosed with Cushing’s caused by advanced adrenal gland cancer, a rare malignancy with a poor prognosis, scientists reported. Her case highlights the difficulties in diagnosing and treating such tumors, particularly during pregnancy, when hormonal changes can camouflage its symptoms. “It is reported that benign and malignant…

The risk of consuming supplements was recently highlighted in a case of a woman with Cushing’s syndrome caused by prolonged use of an over-the-counter arthritis product containing a glucocorticoid. The patient was ultimately diagnosed with Cushing’s based on her typical disease features together with her long exposure to the…

A recent case of a man with Cushing’s disease illustrates a rare psychiatric manifestation of the disease — symptoms of functional neurological disorder (FND), according to a report. FND is where patients experience a series of neurological symptoms in the absence of a neurological disorder. “To our knowledge, this…

A man developed Cushing’s syndrome as a result of an interaction between two medications he was taking — an antiviral therapy to treat chronic infections and an inhaled steroid to manage asthma — according to a recent report. “This clinical case illustrates the importance of a meticulous review of all…

Isturisa (osilodrostat) was found to successfully treat Cushing’s syndrome associated with a hormone-producing tumor in the lungs in a 69-year-old woman with lung cancer, according to a recent case study. The woman simultaneously underwent cancer treatment with Tagrisso (osimertinib), which also was successful. The researchers noted that this case…

Cushing’s syndrome should be considered when osteoporosis, or weak bones, are found in young adults, scientists in China reported. They described treating a 26-year-old woman who came to their clinic with chronic back pain that X-rays identified as due to multiple bone fractures, and who exhibited a number of other…

In people with Cushing’s disease, it is relatively common for blood clots that cause no symptoms — called asymptomatic blood clots — to appear in the legs after surgery, a new study reported. Indeed, in a case series of 30 Cushing’s patients who underwent surgery and screening with compression…

Enrollment is nearly complete for a Phase 3 trial that is investigating the safety and effectiveness of relacorilant in people with Cushing’s syndrome due to any underlying cause, according to a corporate update from its developer, Corcept Therapeutics. The trial, called GRACE (NCT03697109), is enrolling about 130 people…