High levels of white blood cells, particularly neutrophils, without an infectious or blood-related cause may be a sign of subclinical Cushing’s disease, according to a case study. The report describes the case of a woman who had palpitations and fatigue, but no other overt symptoms. She was found to…
A young woman developed Cushing’s disease after she received pain relief treatment for her chronic pancreatitis — a long-lasting inflammation of the pancreas — via a celiac plexus block (CPB) with a corticosteroid called triamcinolone, a U.S. report says. “Although her pain was relieved with CPB, she developed iatrogenic…
A woman who was on Korlym (mifepristone) to treat hyperglycemia, or high blood sugar levels, linked to Cushing’s disease went on to develop liver damage as a side effect of the medicine, according to a U.S. report. This is the third time such a case has been reported.
Magnetic resonance imaging (MRI) is a useful tool for pinpointing the location of a pituitary tumor that causes Cushing’s disease prior to surgery, a recent study reported. However, study findings indicate that bilateral inferior petrosal sinus sampling (BIPSS), an invasive diagnostic procedure, is more accurate for the initial…
People with recurrent Cushing’s disease who are treated with surgery are more likely to go into remission than patients given radiation therapy, a review study has found. “Based on the results of the current study, surgery should be considered as a second-line treatment for recurrent [Cushing’s disease] patients as…
Elderly people with Cushing’s syndrome often experience different symptoms than their younger counterparts, which suggests diagnosis may be more difficult with age, according to a recent study. “Several typical symptoms of [Cushing’s] were less frequent in the older patients as compared with the younger, including weight gain, skin…
The prevalence of infection by SARS-CoV-2, the virus that causes COVID-19, was found to be similar in people with Cushing’s disease to that of the general population, according to an Italian study. The same was seen for patients in Southern Italy with acromegaly, a disorder marked by the…
Signifor (pasireotide) treatment was able to control symptoms of ectopic Cushing’s syndrome in a woman for years, according to a case report. The report, “Complete and sustained remission of hypercortisolism with pasireotide treatment of an adrenocorticotropic hormone (ACTH)-secreting thoracic neuroendocrine tumour: an n-of-1 trial,” was published in…
The U.S. Food and Drug Administration (FDA) has granted Xeris Pharmaceuticals orphan-drug exclusivity for Recorlev (levoketoconazole), its approved treatment for adults with endogenous Cushing’s syndrome. Orphan-drug exclusivity provides the company — which recently acquired the therapy’s developer, Strongbridge Biopharma — seven years of marketing exclusivity for Recorlev…
The case of a woman with adrenal gland cancer that caused Cushing’s syndrome in its advanced stages was described in a recent report. Authors noted this study highlights the difficulties in care for people with aggressive adrenal tumors, which often don’t cause noticeable symptoms until the disease is at a…
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