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Signifor (pasireotide) treatment was able to control symptoms of ectopic Cushing’s syndrome in a woman for years, according to a case report. The report, “Complete and sustained remission of hypercortisolism with pasireotide treatment of an adrenocorticotropic hormone (ACTH)-secreting thoracic neuroendocrine tumour: an n-of-1 trial,” was published in…

The U.S. Food and Drug Administration (FDA) has granted Xeris Pharmaceuticals orphan-drug exclusivity for Recorlev (levoketoconazole), its approved treatment for adults with endogenous Cushing’s syndrome. Orphan-drug exclusivity provides the company — which recently acquired the therapy’s developer, Strongbridge Biopharma — seven years of marketing exclusivity for Recorlev…

The case of a woman with adrenal gland cancer that caused Cushing’s syndrome in its advanced stages was described in a recent report. Authors noted this study highlights the difficulties in care for people with aggressive adrenal tumors, which often don’t cause noticeable symptoms until the disease is at a…

A 33-year-old man with ectopic Cushing’s syndrome saw his symptoms ease after undergoing surgery to remove a rare, slow-growing cancer tumor from his chest. The carcinoid tumor, a type of neuroendocrine tumor, was the cause of the man’s condition, according to researchers. “The patient had complete resolution of symptoms…

Despite advancements in imaging techniques that have improved the detection of Cushing’s disease over the last four decades, no alterations in reported remission and recurrence rates were found for the rare disorder in a new review study. In studies published to date, however, there…

A severe muscle infection and electrolyte imbalances were among clinical signs leading to a Cushing’s syndrome diagnosis in an 82-year-old woman, according to a recent case report. The patient also showed other cardiovascular risk factors for Cushing’s that aided clinicians in their diagnosis. Infectious complications after a surgery caused the…

A 49-year-old woman developed exogenous, or therapy-related, Cushing’s syndrome, after being treated with the antiviral Epclusa, which is approved to treat hepatitis C virus infections, a case study reported. “To our knowledge, this is the first time that [Epclusa] has been linked to [exogenous Cushing’s],” the researchers wrote. The study,…

People with Cushing’s syndrome have significant changes in the levels of adipokines — cell signaling molecules produced by fatty tissue — a recent study reports. Such changes were also found to be associated with urine cortisol levels and blood adrenocorticotropic hormone (ACTH) levels, as well as several metabolic parameters.

In rare cases, proximal muscle weakness may be the only indication of Cushing’s disease, a recent case report showed. The patient, a 36-year-old man, was initially misdiagnosed with dermatomyositis, a rare disease that causes muscle inflammation and skin rash. The report, “Proximal muscle weakness as the sole manifestation…

A rare tumor in the prostate gland triggered Cushing’s syndrome in a man, a case study from Lebanon reports. The report, “ACTH-secreting metastatic prostate cancer with neuroendocrine differentiation,” was published in BMJ Case Reports. Cushing’s syndrome is caused by an excess of cortisol in the body. It sometimes…