Not many people who are very obese have Cushing’s syndrome, but a low-dose dexamethasone test may help distinguish who has the disease from who doesn’t before weight loss surgery, a Turkish study has reported. The study, “Assessment of the diagnostic performance of the 1 mg dexamethasone suppression test in…
News
A young man switched his standard diet to a ketogenic, or “keto,” diet that’s low in carbohydrates and high in fats to lose weight, and saw some of his symptoms of Cushing’s disease ease, according to a new report. But he wasn’t diagnosed until his symptoms came back or…
Eating licorice can increase the amount of cortisol detected in saliva, but licorice consumption does not alter salivary levels of a cortisol metabolite called cortisone, a recent study has found. Cortisone also is less variable in response to other confounding variables, and researchers proposed salivary cortisone may be a more…
PROP1, a pituitary gland protein that regulates gene activity related to hormone production, may play a role in the development of noncancerous tumors that cause Cushing’s disease, a small preliminary study suggested. According to researchers, PROP1 may be a therapeutic target for pituitary tumors. Future studies involving a larger…
Measuring the ratio of cortisol to adrenocorticotropic hormone (ACTH) could help diagnose Cushing’s disease and other forms of Cushing’s syndrome, according to a recent study. “We think that it is possible to diagnose and screening [ACTH-independent Cushing’s syndrome] when CAR [cortisol-to-ACTH ratio] is elevated, and screening CD [Cushing’s disease]…
Recorlev (levoketoconazole) outperformed a placebo at normalizing urine cortisol levels among people with endogenous Cushing’s syndrome in the Phase 3 LOGICS trial. Top-line data from the study were announced in 2020. Full results have now been published in Pituitary in the study, “Levoketoconazole in the treatment…
Long-term treatment with Recorlev (levoketoconazole) safely leads to sustained reductions in cortisol levels, disease signs and symptoms, and improvements in quality of life in adults with endogenous Cushing’s syndrome, according to nearly two years of data from the Phase 3 SONICS trial. Treatment benefits were generally maintained or deepened…
“Mini pituitary tumors” derived from patients, including those with Cushing’s disease, mimic several features of the individual’s tumor, including response to treatments, a study shows. These pituitary tumor-like organoids can serve as models for studies of the underlying molecular mechanisms of Cushing’s disease and to screen for the most…
Pneumocystis pneumonia, a serious infectious complication of Cushing’s syndrome, is associated with a high mortality rate, researchers in France report. The onset of infection tends to occur shortly after beginning therapy to reduce cortisol levels, and is more frequent in patients with cancer-related Cushing’s and/or high levels of cortisol.
A 71-year-old woman with ectopic Cushing’s syndrome saw her clinical symptoms ease after undergoing surgery to remove several nodules from her left lung. One nodule removed was a carcinoid tumor producing adrenocorticotropic hormone (ACTH), while another was due to a lung infection caused by the fungus Cryptococcus. Her infection was associated with immunodeficiency…
Recent Posts
- Older Cushing’s patients more likely to need long-term steroids after surgery
- CSRF goals for Cushing’s awareness month: Educate, fund vital research
- Before meds, Cushing’s disease resulted in the loss of my period
- Woman’s Cushing’s diagnosis missed before weight-loss surgery: Report
- How living with Cushing’s disease is like a modern-day ‘Moby-Dick’
- Negative MRI linked to lower surgery success rate in Cushing’s disease
- Woman’s ultra rare spinal condition caused by Cushing’s disease: Report
- I find myself struggling to manage the complications of Cushing’s disease
- Urine test improves reliability of Cushing’s syndrome diagnosis: Study
- Issues with brain’s ‘sewer system’ may spur cognitive problems in Cushing’s