Sleep quality markedly improves for people with endogenous Cushing’s syndrome after treatment leads to disease remission, but nearly half of these patients continue to experience sleep disturbances. Those are the findings of a single-center study in the U.S. that also demonstrated that the proportion of Cushing’s patients taking medications for…

Cushing’s disease caused by Crooke cell adenoma — a rare but typically more aggressive pituitary tumor — is less likely than forms of the disease associated with other types of pituitary tumors to go into remission in the months following surgery. This is true despite the fact that surgery…

People with Cushing’s disease who achieve remission — no matter how long that takes — are more likely to live a longer life than are patients who have active disease, a 20-year study found. Achieving remission, which is when symptoms ease or disappear, was linked to fewer deaths, also…

People with Cushing’s disease who have been in remission for years may have an imbalance in their gut microbiome — the group of all microorganisms living in the gut — and this may be the reason why their cardiovascular risk persists, a pilot study suggests. The small study included…

Removing a pituitary tumor through the nostrils with an endoscope led to shorter recovery times for patients with Cushing’s disease than for those who had the surgery through the traditional microscopic approach, a study reports. However, similar remission, recurrence, and complication rates were found between patients, regardless of the…

People with active Cushing’s disease have a smaller volume of gray matter — the outer layer of the brain extending into the spinal cord, where most nerve and other cells are found — and an unusual distribution of iron in the brain, a study reported. Importantly, abnormal iron redistribution…

For years before and after their diagnosis, people with Cushing’s disease use more psychotropic medications — those that affect mood, thoughts, or perception — for mental health problems than their healthy peers, a study in Sweden found. Notably, patients experiencing long-term disease remission still showed higher use of antidepressants…

Proper characterization of the features of double pituitary adenomas in patients with Cushing’s disease is key for an accurate diagnosis and successful surgical removal, a study highlights. The study, “Double Pituitary Adenomas in a Large Surgical Series,” was published in the journal Pituitary. Most pituitary adenomas…

In patients with Cushing’s disease, removing the pituitary tumor via an endoscopic transsphenoidal surgery (TSS) leads to better remission rates than microscopic TSS, according to new research. But regardless of surgical approach, plasma cortisol levels one day after surgery are predictive of remission, researchers found. The study, “…

Pituitary surgery that restores healthy cortisol levels in people with Cushing’s disease only partly reverses changes in the brain that were caused by excessive levels, a study from China reports. Specifically, the surgery partly normalizes gray matter volume, where most nerve and other cells are found, but alterations to the…