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A combination of two noninvasive tests — the dexamethasone suppression test and high-resolution MRI scans — was found to correctly distinguish between Cushing’s disease and ectopic Cushing’s syndrome in patients, according to a new study. The accuracy seen in combining these tests was comparable to that of bilateral inferior…

A pituitary tumor and thyroid cancer were found in a 43-year-old woman with cyclic Cushing’s syndrome, a form of Cushing’s in which cortisol levels rise and fall over time, according to a case report from China. The researchers noted that such fluctuations in a person’s cortisol levels can throw off…

People with endogenous Cushing’s syndrome face a higher risk of cancer compared with the general population, and are twice as likely to develop cancers within 10 years of their diagnosis, according to a new study from Israel. Being 60 or older, male, or having adrenal Cushing’s — a form of…

A rare type of nasal tumor called olfactory neuroblastoma caused ectopic Cushing’s syndrome in a 56-year-old woman, according to a recent case report. The condition was effectively managed with the cortisol-lowering medication metyrapone before being followed by surgery and radiotherapy. After starting metyrapone, the woman developed an opportunistic lung infection,…

People with Cushing’s syndrome commonly lose weight after the disorder is treated, a new study found. Findings indicate that nearly half of Cushing’s patients who achieve disease remission lose at least 5% of their total body weight in the years following treatment, and nearly a third lose 10% or…

Prolonged use of high-dose corticosteroid nasal sprays can lead to Cushing’s syndrome in children, according to a case report on a young girl in Italy who was treated with intranasal betamethasone and mometasone furoate for nasal congestion. While it’s well known that Cushing’s syndrome can…

Korlym (mifepristone) lowered the levels of hemoglobin A1c (HbA1c), which reflects the average amount of blood sugar over the past three months, in people with Cushing’s syndrome and treatment-resistant type 2 diabetes. That’s according to newly published data from the now-complete Phase 4 CATALYST (NCT05772169) clinical trial, which…

The first participant has been dosed in a Phase 2 clinical trial testing ST-002 in people with Cushing’s syndrome and high blood sugar levels. “ST-002 has the potential to change the treatment landscape for patients who currently have limited therapeutic options,” Manohar Katakam, PhD, CEO of treatment developer Sterotherapeutics,…

Early screening and treatment for possible underlying causes of obesity, such as Cushing’s disease, before a weight-loss procedure called bariatric surgery may help prevent mismanaging the condition and improve patient outcomes. That’s according to a report that described the case of a man in Iraq who developed complications and…

Sequential treatment with ketoconazole to lower cortisol levels and octreotide to help keep cortisol under control may be effective as a treatment for a subset of people with mild Cushing’s disease, according to a study from the Netherlands. Two of the three patients who responded to treatment, reflected…