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2 women with Cushing’s disease use metyrapone throughout pregnancy

Two women with Cushing’s disease successfully used the cortisol-lowering medication metyrapone during their pregnancy, a case study shows. “Metyrapone represents a viable option for managing [Cushing’s disease] throughout pregnancy when surgical intervention is contraindicated or declined, although careful monitoring and dose optimization are essential,” the researchers wrote. The cases…

ACTH-producing thymus tumor caused ectopic Cushing’s in woman

A woman in her early 30s who developed severe ectopic Cushing’s syndrome due to a small thymus tumor was effectively managed with medications to reduce cortisol levels followed by surgery, according to a case report from Poland. After the initial surgery, the patient experienced two recurrences of Cushing’s within seven…

Signifor effective in half of Cushing’s disease patients: Study

Treatment with Signifor (pasireotide) normalized urinary cortisol levels in about half of adults with Cushing’s disease, regardless of their gender, a small real-world study suggests. Because treatment response was associated with the absence of diabetes before treatment, researchers suggest proper blood sugar management in patients planning to start…