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Treatment with Signifor (pasireotide) normalized urinary cortisol levels in about half of adults with Cushing’s disease, regardless of their gender, a small real-world study suggests. Because treatment response was associated with the absence of diabetes before treatment, researchers suggest proper blood sugar management in patients planning to start…

A woman in Switzerland with metastatic lung cancer who developed thin skin and was later diagnosed with Cushing’s syndrome was the subject of a repoort by researchers. Metastatic cancer occurs when the disease has spread from its original site to other parts of the body. In this case, Cushing’s was…

An 8-year-old girl was diagnosed with primary pigmented nodular adrenocortical disease (PPNAD), a rare genetic disorder that can cause Cushing’s syndrome, a case study reports. Hers was the first reported case of PPNAD caused by a duplication in the PRKACA gene. according to the researchers. The girl’s case was described in…

  A clinical trial aims to assess the prevalence of Cushing’s syndrome in adults with hard-to-treat high blood pressure. The trial, called MOMENTUM (NCT06829537), plans to recruit 1,000 adults with hypertension (high blood pressure) that remains uncontrolled despite the use of at least three different types of medications designed…

A young woman with Cushing’s disease and acromegaly — marked by the abnormal growth of certain body parts due to pituitary gland dysfunction — saw her symptoms ease after undergoing surgery to remove a large hormone-producing tumor that caused both rare conditions, a study from Bangladesh reported. “The…

The U.S. Food and Drug Administration (FDA) has accepted an application from Corcept Therapeutics seeking the approval of relacorilant as a treatment for people with endogenous Cushing’s syndrome. A decision from the FDA is now expected by Dec. 30, according to the company. “The FDA’s acceptance of our…

People with Cushing’s disease who have more education are also more likely to have better patient outcomes — including longer survival — than those with lower educational levels, a study in Sweden found. According to the study, which followed individuals with Cushing’s for as long as 20 years before…

Sterotherapeutics has announced the launch of a Phase 2 clinical trial to test its experimental therapy ST-002 in people with Cushing’s syndrome. “This trial represents a significant step forward in our mission to develop transformative therapies for unmet medical needs,” Manohar Katakam, PhD, CEO of Sterotherapeutics, said in…

In rare cases, Cushing’s syndrome can be caused by tumors that are simultaneously producing two signaling molecules called adrenocorticotropic hormone (ACTH) and corticotropin-releasing hormone (CRH). Diagnosing Cushing’s in these cases can be complex, leading to delays in treatment and worse outcomes for patients, according to a new report. “Studies…

One person out of five with Cushing’s syndrome in Israel has higher than normal numbers of white blood cells that drop within two years after surgery, but may still remain higher than the general population, a study finds.  Patients with Cushing’s disease, a specific type of Cushing’s syndrome…