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After surgery for Cushing’s disease, very low levels of cortisol in the morning strongly predict that a patient will recover and remain disease-free long term, a new study from a quartet of researchers in Germany has found. Remission was shown to be especially likely for Cushing’s patients with a…

Elevated levels of cortisol, or hypercortisolism, a hallmark of Cushing’s syndrome, are present in over a quarter of people with treatment-resistant high blood pressure (hypertension), according to a study. Results come from the MOMENTUM observational trial (NCT06829537), which enrolled more than 1,080 adults with uncontrolled hypertension despite the use…

An artificial intelligence (AI)-designed small molecule that targets the NR3C1 gene may offer a safer, more effective treatment for Cushing’s syndrome by counteracting excess cortisol. Insilico Medicine said it will focus on its molecule, ISM6200, as a promising new drug that may become a leading treatment for ovarian cancer,…

Patients who are 45 or older when they have surgery for Cushing’s disease are more likely to need long-term hormone replacement therapy, according to a new study. Researchers found that prolonged medication use, lasting 20 months or more, is associated with lower survival odds for those with pituitary-driven Cushing’s.

April is Cushing’s Awareness Month, a global effort during which advocacy groups — such as the Cushing’s Support & Research Foundation (CSRF), launched in 1995 — healthcare professionals, and patients organize campaigns, share information, and take part in events to educate the public about the condition, caused by an…

Early screening for underlying causes of obesity before weight-loss surgery, including Cushing’s syndrome in individuals with suggestive signs, may help improve outcomes and reduce unnecessary procedures. That’s according to a report that described the case of a woman in Saudi Arabia who underwent unsuccessful bariatric surgery and was ultimately…

People with Cushing’s disease who don’t have a disease-causing tumor visible on MRI scans are less likely to experience full symptom control following pituitary surgery, a new study shows. Researchers think the lower success rate in these patients may be due to some individuals having corticotroph hyperplasia, an underrecognized…

Cushing’s disease was identified as the underlying cause of spinal epidural lipomatosis (SEL) — a rare condition marked by the buildup of fat in the space around the spinal cord — in a 62-year-old woman with progressive leg weakness who had to undergo immediate spinal decompression surgery. Both that…

A urine test that measures cortisol, cortisone, and dexamethasone simultaneously can improve the reliability of 24-hour urinary free cortisol (UFC) testing for diagnosing Cushing’s syndrome, including Cushing’s disease, according to a study It also helps detect interfering medications and provides doctors with additional biomarkers for more accurate…

In people with Cushing’s disease, high cortisol levels can lead to problems with a key system that clears waste from the brain, and dysfunction of this system may set the stage for damage to the brain that leads to cognitive issues in some Cushing’s patients, according to a study.