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January 7, 2020January 7, 2020

Childhood Cushing’s Patients May Experience Long-Term Hormonal Deficits, Mood Disorders

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People diagnosed with Cushing’s disease during childhood may experience lowered pituitary hormones long after receiving surgery, as well as mood and cognitive disorders, a long-term follow-up study shows. The ... Read more

January 2, 2020

BIPSS Diagnostic Method May Cause False Positive in Some Cases of Cyclic Cushing’s Syndrome, Case Study Suggests

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A diagnostic technique called bilateral inferior petrosal sinus sampling (BIPSS), which measures the levels of the adrenocorticotropic hormone (ACTH) produced by the pituitary gland, should only be used to ... Read more

December 19, 2019

Tumor Surgery Quickly Eases Hypertension in Most Cushing’s Syndrome Patients, Study Finds

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People with Cushing’s syndrome often experience a rise in blood pressure that puts them at a significant risk of cardiovascular ills, but most improve within 10 days after surgery ... Read more

December 17, 2019December 17, 2019

Cabergoline Reduces Efficacy of Radiotherapy in Cushing’s Disease, Small Study Suggests

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Cushing’s disease patients who are treated with cabergoline while undergoing conventional fractionated radiotherapy have a higher risk of disease recurrence after initial remission, a small study has found. The ... Read more

December 12, 2019

Cushing’s Patients Wait Almost 3 Years for Confirmed Diagnosis, German Study Finds

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On average, people with Cushing’s syndrome wait 34 months before receiving a definite diagnosis, but waiting time largely depends on their specific disease subtype, a review study from Germany ... Read more

December 10, 2019

Phase 3 Trial of Relacorilant in Endogenous Cushing’s Patients Starts Dosing in Europe

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A Phase 3 trial evaluating Corcept Therapeutics‘ relacorilant in treating the high blood pressure and poorer glucose tolerance in people with endogenous Cushing’s syndrome has begun dosing patients in ... Read more

December 5, 2019

HHS Secretary Alex Azar Touts White House Efforts to Cure Rare Diseases

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Despite skyrocketing healthcare costs, President Trump is committed to protecting the 30 million or so Americans with rare diseases and ensuring timely, affordable access to lifesaving treatments, the nation’s ... Read more

November 26, 2019November 26, 2019

EMA’s CHMP Recommends Approval of Isturisa as Treatment for Cushing’s Syndrome

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A European Medicines Agency (EMA) committee has recommended the approval of osilodrostat — to be marketed as Isturisa — for the treatment of adults with Cushing’s syndrome. Osilodrostat, formerly ... Read more

November 15, 2019November 16, 2019

Rare Disease Film Festival Highlights Patient and Researcher Unity

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Rare disease-themed videos glowed on a large screen before an audience of people in wheelchairs, with crutches, and bearing oxygen tanks this Nov. 9 and 10 in San Francisco. ... Read more

November 14, 2019

USP8 May Be Potential Target for Cushing’s Disease Therapy, Mouse Cell Study Suggests

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Targeting the USP8 protein, which is frequently mutated in Cushing’s disease patients, lowered the levels of adrenocorticotropic hormone, inhibited cell proliferation, and caused cell death in a mouse cell ... Read more

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