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November 15, 2019November 16, 2019

Rare Disease Film Festival Highlights Patient and Researcher Unity

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Rare disease-themed videos glowed on a large screen before an audience of people in wheelchairs, with crutches, and bearing oxygen tanks this Nov. 9 and 10 in San Francisco. ... Read more

November 14, 2019

USP8 May Be Potential Target for Cushing’s Disease Therapy, Mouse Cell Study Suggests

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Targeting the USP8 protein, which is frequently mutated in Cushing’s disease patients, lowered the levels of adrenocorticotropic hormone, inhibited cell proliferation, and caused cell death in a mouse cell ... Read more

November 12, 2019

Symptoms Linked With Cardiovascular Risk More Prevalent in Subclinical Cushing’s, Review Finds

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Symptoms associated with the risk of heart disease or stroke are common in people with asymptomatic tumors of the adrenal glands – called adrenal incidentalomas – particularly those that ... Read more

November 7, 2019

Blood Clot Risk in Cushing’s Disease Patients May Extend Well Beyond Pituitary Surgery, Case Study Finds

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People with Cushing’s disease are much more likely than others to develop blood clots, including rare ones in the brain, even after a pituitary surgery normalizes their cortisol levels, ... Read more

November 5, 2019

Genetic Variations of Glucocorticoid Receptor May Explain Loss of Muscle Strength in Cushing’s, Study Says

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Genetic variations in the glucocorticoid receptor may explain why some patients with Cushing’s syndrome lose muscle strength, a study suggests. The study, “Glucocorticoid receptor polymorphisms influence muscle strength in ... Read more

October 31, 2019

Doctors Should Suspect Cushing’s Syndrome in Cases of Treatment-resistant Depression, Report Suggests

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Doctors should suspect Cushing’s syndrome in cases of depression that do not respond to medication or other interventions, avoiding misdiagnosis and unnecessary treatment, a case report suggests. While reducing cortisol ... Read more

October 29, 2019

Long-term Topical Corticosteroid Use can Cause Secondary Cushing’s Syndrome in Adults, Case Report Shows

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Long-term use of topical corticosteroids to treat skin problems can trigger secondary Cushing’s syndrome in adults, with a severe impact on bone health, a case report shows. The study, ... Read more

October 24, 2019

Poor Fat Metabolism and Insulin Resistance Linked to Bone Loss, Fracture Risk in Cushing’s Patients

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Abnormal fat accumulation, including increased bone marrow fat and insulin resistance, can lead to bone loss and a greater likelihood of fractures in people with Cushing’s disease, researchers report. ... Read more

October 22, 2019

Accurate Characterization of Double Pituitary Adenomas is Key in Cushing’s Patients, Study Reports

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Proper characterization of the features of double pituitary adenomas in patients with Cushing’s disease is key for an accurate diagnosis and successful surgical removal, a study highlights. The study, ... Read more

October 17, 2019

Removing Adrenal Glands May Help with Cortisol Control in Difficult-to-treat Patients, Study Reports

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Surgically removing both adrenal glands is a safe and effective way to control excessive cortisol levels in people with Cushing’s disease who fail to improve after pituitary surgery or ... Read more

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