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August 16, 2018

OvaScience, Millendo Therapeutics Merge to Advance Cushings’s and PWS Therapies

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OvaScience and Millendo Therapeutics will merge in an all-stock deal to push forward Millendo’s lead candidates livoletide (AZP-531) and nevanimibe (ATR-101) for the treatment of Prader-Willi syndrome and Cushing’s ... Read more

August 14, 2018

Recorlev Shows Promise for Endogenous Cushing’s Syndrome, Results Show

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Recorlev (levoketoconazole) safely and successfully reduces the levels of cortisol in patients with endogenous Cushing’s syndrome, according to top-line results of a Phase 3 clinical trial. Cushing’s syndrome occurs due ... Read more

August 10, 2018

ACTH Suppression Test Predicts Remission After Pituitary Tumor Removal, Study Shows

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A test using betamethasone — a corticosteroid that causes the pituitary gland to stop producing ACTH – can accurately predict short- and long-term remission in Cushing’s disease patients who have had pituitary surgery, a ... Read more

August 9, 2018

Korlym as Good as Adrenal Surgery for Treating Ectopic Cushing’s Syndrome, Study Finds

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Korlym (mifepristone) is effective for the treatment of ectopic Cushing’s syndrome patients, with survival rates comparable to patients who undergo bilateral adrenalectomy (removal of the adrenal glands), new research ... Read more

August 7, 2018

Nationality Influences How Cushing’s Patients Grade Quality of Life, Study Contends

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American and Dutch patients with Cushing’s syndrome have different ways of interpreting the same items on a disease-specific quality-of-life (QoL) questionnaire, research shows. The study, “Assessing Differences in How ... Read more

August 2, 2018

Metformin, Oral Diabetes Treatment, Limits Growth of Tumors That Cause Cushing’s in Early Study

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Metformin, an oral type 2 diabetes medicine, can promote cell death in tumors that cause Cushing’s disease and reduce the excessive production of the adrenocorticotroph hormone (ACTH) that underlies ... Read more

July 31, 2018July 31, 2018

Night Cortisol Levels for Diagnosing Cushing’s Syndrome Less Accurate in Clinical Practice, Study Finds

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Salivary cortisol levels can be used to diagnose Cushing’s syndrome with relatively high reliability, but each test center should establish its own measurement limits depending on the exact method ... Read more

July 26, 2018

Transsphenoidal Surgery Is Safe and Effective Treatment for Cushing’s Disease, Study Shows

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Transsphenoidal surgery, a minimally invasive surgery to remove tumors in the pituitary gland, is safe and effective to treat Cushing’s disease, a 20-year history of cases in a Belgian ... Read more

July 24, 2018

Metyrapone Rapidly Reduces Cortisol Levels in Cushing’s Syndrome Patients, Real-Life Study Shows

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Treatment with metyrapone rapidly reduces cortisol levels in Cushing’s syndrome patients and keeps them low over the long term, a real-life study shows. The study, “Metyrapone treatment in Cushing’s syndrome: a real-life ... Read more

July 19, 2018

Cushing’s Patients with USP8-mutant Tumors Have More Frequent Relapses Sooner After Surgery, Study Shows

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Patients with Cushing’s disease whose pituitary tumors bear mutations in the USP8 gene are more likely to experience recurrence, and develop them sooner after surgery, a new study shows. The study, ... Read more

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