Long-term treatment with relacorilant led to a sustained decrease in blood pressure, blood sugar levels, and body weight in people with Cushing’s syndrome, new data from an extension study shows. The extension study (NCT03604198) is assessing relacorilant’s long-term safety and efficacy in 116 people with Cushing’s who completed…
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Korlym (mifepristone) significantly reduced levels of hemoglobin A1c, a marker that reflects blood sugar levels over the previous months, in people with Cushing’s syndrome and difficult-to-control type 2 diabetes. That’s according to new data from a Phase 4 clinical trial, CATALYST (NCT05772169), which screened 1,057 patients with difficult-to-control…
An elderly woman developed Cushing’s syndrome after a year of using a so-called magic mouthwash — a rinse containing a potent topical corticosteroid — to treat an inflammatory disease affecting the mouth, according to a case study from Australia. About two months after stopping use of the steroid mouthwash,…
Patients being treated with Isturisa (osilodrostat) for Cushing’s disease see better long-term clinical outcomes when both late-night salivary cortisol and mean urinary free cortisol returned to normal levels, instead of just one or neither of those measures. Drawing on data from two Phase 3 clinical studies, LINC-3…
A protein called ACBP mediates the relationship between elevated levels of cortisol, the hallmark feature of Cushing’s syndrome, and the development of associated symptoms, according to a mouse study led by researchers in France. Using several methods to suppress ACBP activity, the researchers abolished Cushing’s signs in the mice —…
People with Cushing’s syndrome have soft bones, even after being in remission for a long time, a study reported. Despite having comparable bone mineral density, a standard measure of bone health based on its mineral content, Cushing’s patients in remission scored significantly lower on the material strength index (BMSi), an…
The diagnosis of a 33-year-old woman with Cushing’s disease was delayed due to the presence of mild, nonspecific symptoms, a tumor in the adrenal glands, and normal blood levels of the adrenocorticotropic hormone (ACTH), according to a new case study. The woman’s move from Canada to the U.K. also…
Ectopic Cushing’s syndrome in a 10-year-old girl that was caused by a thymus tumor was effectively managed with ketoconazole and surgery to remove the thymus, according to a case report from the Czech Republic. “This case presents some unique challenges related to the diagnosis, management, and treatment of thymic…
People with Cushing’s syndrome are at a high risk of glaucoma — an eye condition in which the optic nerve that connects the eye and brain becomes damaged, potentially leading to vision loss — according to a new study that found the risk for Cushing’s patients is 74% greater than…
People with Cushing’s disease frequently experience cognitive and psychiatric complications, often persisting after surgery to remove the disease-driving tumor, a review study noted. That could be because high cortisol levels during active phases of Cushing’s disease can cause physical changes in brain structure that persist after cortisol levels are…
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