News

A rare type of tumor caused Cushing’s syndrome with unusual symptoms, including brain damage and hallucinations, in a 72-year-old woman, according to a recent case report. The disease-causing tumor was removed, and researchers report that the patient is now fully recovered, with partial resolution of the disease-associated brain damage. The…

A type of minimally invasive surgery to remove pituitary tumors through the nose, called endoscopic transsphenoidal surgery, was found to be safe and led to remission from Cushing’s disease, with patients seeing no recurrences, a study in China reports. The procedure involved identifying pituitary and tumor layers before the…

An antifungal medication called ketoconazole may be safe and effective for treating Cushing’s disease when pituitary surgery to remove a disease-causing tumor has failed to lower cortisol levels in the body, according to a new meta-analysis study. Researchers found that in nearly two-thirds of cases reported in the literature,…

A high-resolution MRI outperformed other types of MRI at detecting microadenomas — small benign (noncancerous) tumors that form in the brain’s pituitary gland and can cause Cushing’s disease. In a small study from China, about four in five people with Cushing’s received a correct diagnosis of a microadenoma with…

A man with Cushing’s syndrome developed a rare Mycobacterium szulgai skin infection after cleaning his tropical fish tank, a study in China reported. This mycobacterium is typically found in environmental water sources, including hospital taps, ice machines, fish tanks, and swimming pools, and most reported cases of infection in humans…

Double pituitary adenomas — noncancerous tumors that cause Cushing’s disease — were detected in up to 13% of patients having tumor removal surgery at a hospital in Ukraine, a study reports. While MRI scans detected some of the additional tumors, others were discovered by a comprehensive inspection of the…

The accuracy of late-night testing of cortisol levels in saliva — a common test for diagnosing Cushing’s syndrome — may be lower in real-world clinical practice than in controlled experimental settings, according to a new study from Turkey. The results showed the sensitivity, or true positive rate, of the late-night…

Genetic variations were not significantly associated with the time to recovery of adrenal function following surgery for Cushing’s disease, an exploratory study reported. According to the researchers, these findings indicate that other factors, such as surgical and clinical factors, are likely more relevant to define the timing of adrenal…

The Phase 3 GRACE trial that’s testing relacorilant in people with Cushing’s syndrome is expected to finish enrolling participants in the coming weeks, according to a recent corporate update from its developer, Corcept Therapeutics. Assuming the trial’s findings are positive, Corcept expects to use its data as the basis…

A 47-year-old woman with Cushing’s disease was initially misdiagnosed with an anxiety disorder, ultimately leading to her developing additional complications, scientists in China reported. The woman was diagnosed with Cushing’s disease after an ineffective psychiatric intervention, but continued taking high doses of psychiatric medications after surgery to remove a…