News

The accuracy of late-night testing of cortisol levels in saliva — a common test for diagnosing Cushing’s syndrome — may be lower in real-world clinical practice than in controlled experimental settings, according to a new study from Turkey. The results showed the sensitivity, or true positive rate, of the late-night…

Genetic variations were not significantly associated with the time to recovery of adrenal function following surgery for Cushing’s disease, an exploratory study reported. According to the researchers, these findings indicate that other factors, such as surgical and clinical factors, are likely more relevant to define the timing of adrenal…

The Phase 3 GRACE trial that’s testing relacorilant in people with Cushing’s syndrome is expected to finish enrolling participants in the coming weeks, according to a recent corporate update from its developer, Corcept Therapeutics. Assuming the trial’s findings are positive, Corcept expects to use its data as the basis…

A 47-year-old woman with Cushing’s disease was initially misdiagnosed with an anxiety disorder, ultimately leading to her developing additional complications, scientists in China reported. The woman was diagnosed with Cushing’s disease after an ineffective psychiatric intervention, but continued taking high doses of psychiatric medications after surgery to remove a…

A woman developed Cushing’s syndrome as a result of a pheochromocytoma, a usually benign non-cancerous tumor that forms in the adrenal glands above the kidneys, a case study from Portugal reports. Because it’s so rare, “this diagnosis demands a high level of clinical suspicion and should be equated in the…

People with Cushing’s syndrome have a high disease burden linked to persistent symptoms of weight gain, pain, and anxiety, despite being treated, a recent study reported. These observations highlight the need for interventions that address these persistent symptoms and “underscore the importance of the patient’s perspective in clinical decision making…

A rare case of Cushing’s syndrome in a 3-month-old girl was traced to a medication error involving glucocorticoid, with the infant having been given an oral liquid formulation of omeprazole, prepared by a local pharmacist, that contained small amounts of the steroid hormone. The baby was being treated with omeprazole —…

A 46-year-old woman with a history of Cushing’s disease had a heart attack from an unusual cause — a tear in the coronary artery not due to trauma — and her disease may have contributed to the attack, scientists reported. A spontaneous tear, or dissection, in the wall of…

Low-grade inflammation persisted in people with Cushing’s syndrome one year after surgery to remove disease-causing tumors that led to excess cortisol, the hallmark of the condition, a recent study revealed. High levels of inflammatory markers were associated significantly with post-surgical obesity, high blood sugar levels, and worse long-term muscle function,…

A federal court ruling in Texas that reversed the U.S. Food and Drug Administration’s (FDA) 23-year-old approval of mifepristone has been met with deep concern by the Endocrine Society. Mifepristone, the active ingredient in Mifeprex, is used to end a pregnancy. It’s also the active ingredient of Korlym,…