News

The Phase 3 GRACE trial testing relacorilant in people with Cushing’s syndrome has completed enrollment and data from it is expected next year, according to a recent corporate update from Corcept Therapeutics, its developer. The company plans to submit a new drug application (NDA) to U.S. authorities to market…

People with Cushing’s syndrome, including those with Cushing’s disease, exhibit immune system alterations that could contribute to some symptoms of the disease, a small study suggests. Analyses of immune cells from Cushing’s patients indicated signs of both systemic (whole body) inflammation as well as immunosuppression, which scientists believe might…

A 52-year-old man developed Cushing’s syndrome after taking Artri King, adding to the list of reports that link the supplement to developing the condition. The man had been taking Artri King for his arthritis for 1.5 years, but abruptly stopped after having Cushing’s-like symptoms. His abrupt cessation is…

A woman who developed Cushing’s syndrome caused by an adenoma — a benign tumor in the adrenal gland — saw her symptoms ease after she had surgery to remove the gland, scientists in Nepal reported. In rare cases, adrenal adenomas are associated with high levels of metanephrine, a byproduct of…

Young people with Cushing’s disease who have low bone density also tend to have low levels of insulin-like growth factor 1 (IGF-1), a signaling molecule that’s known to play key roles in bone development, a new study shows. “Our study found that a higher IGF-1 index was independently and significantly…

A woman who developed Cushing’s syndrome as a complication of kidney cancer saw her symptoms fully resolve after the tumor was surgically removed. This is the first published account that definitively describes Cushing’s syndrome developing as a paraneoplastic (cancer-related) complication of this type of cancer and resolving after its removal,…

A 37-year-old woman diagnosed with Cushing’s disease following childbirth experienced a pulmonary embolism — a blockage in blood flow to the lungs that’s generally caused by blood clots — as one of the first symptoms of the rare disorder. According to clinicians, her case highlights that pulmonary embolism may…

A 40-year-old woman developed exogenous, or therapy-related, Cushing’s syndrome, after taking an over-the-counter supplement called Artri King that contained undisclosed glucocorticoids, a case study reports. The woman’s symptoms eased after she stopped taking the supplement, but this is the third study to report an association between products like Artri King…

Cushing’s disease caused a bowel perforation — a rare complication in which a hole in the intestine allows its contents to leak — requiring a young man in Japan to undergo emergency surgery. His case was described in the report “Bowel perforation associated with Cushing’s disease: a case…

A 17-year old girl with Cushing’s syndrome developed atypical features of depression that were accompanied by suicide attempts and acute psychosis, both rarely reported in these patients. According to the case study’s authors, people with Cushing’s syndrome often experience depression, but this can have a wide range of manifestations…