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The first participant has been dosed in a Phase 2 clinical trial testing SPI-62 as a treatment for people with ACTH-dependent forms of Cushing’s syndrome, including Cushing’s disease. That’s according to developer Sparrow Pharmaceuticals, which is evaluating the safety and effectiveness of the oral therapy. “Dosing our first…

Prolonged use of glucocorticoids to reduce inflammation triggered by facial dermal filler procedures likely caused Cushing’s syndrome in a 45-year-old woman, a case report describes. Long-term use of glucocorticoids should be avoided in such cases in favor of alternative treatments, its author noted. The report, “Case…

Cushing’s disease-causing tumors that harbor a mutation in the TP53 gene are generally larger, more invasive, and linked to poorer clinical outcomes, a new study reports. The study, “TP53 mutations in functional corticotroph tumors are linked to invasion and worse clinical outcome,” was published in Acta…

A minimally invasive procedure called central venous sampling (CVS) may help in the diagnosis of Cushing’s disease in people with a disease-causing pituitary tumor that is not detected by MRI scans, a study suggests. CVS, which measures the levels of the adrenocorticotropic hormone (ACTH) from the brain’s pituitary gland,…

A woman developed Cushing’s syndrome following a medullary thyroid cancer that arose due to a mutation in a gene called RET, but her symptoms eased after starting Retsevmo (selpercatinib), a cancer medication, according to a report from France. The report, “Rapid and long-lasting response to selpercatinib of paraneoplastic Cushing’s…

Problem-solving therapy (PST) may improve coping skills and mental health in people with Cushing’s disease by reducing negative attitudes toward problem-solving, depressive symptoms, and perceived stress, a new study has found. The study, “Problem-solving therapy can reduce psychological distress in patients with Cushing’s disease: a randomized controlled trial,”…

Single-cell analysis of non-cancerous pituitary gland tumors that cause Cushing’s disease identified a novel therapeutic target with the potential to suppress tumor cell growth, a study has revealed. Although cells from such tumors, called adenomas, had excess production of noxa — a protein that stimulates cell death — noxa…

People with Cushing’s syndrome are at an increased risk of developing problems related to their bones or blood vessels due to excessive cortisol, a study highlighted. Problems in both these areas — the bones and the blood vessels — can also co-occur, its scientists reported. The study, “…

Treatment with Isturisa (osilodrostat) for 1.5 years or longer kept urine cortisol levels close to normal in patients with Cushing’s disease, and this translated into fewer symptoms with no new side effects, a study has found. The findings come from an extension of LINC-3 (NCT02180217), a Phase…

Researchers have identified risk factors for kidney impairment in adults with Cushing’s syndrome after they undergo surgery to remove their adrenal glands. These factors include having low pre-operative adrenocorticotropic hormone (ACTH) levels or taking higher steroid replacement doses after the surgery. “Disease activity represented by ACTH levels or the steroid…