A urine test that measures cortisol, cortisone, and dexamethasone simultaneously can improve the reliability of 24-hour urinary free cortisol (UFC) testing for diagnosing Cushing’s syndrome, including Cushing’s disease, according to a study It also helps detect interfering medications and provides doctors with additional biomarkers for more accurate…
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In people with Cushing’s disease, high cortisol levels can lead to problems with a key system that clears waste from the brain, and dysfunction of this system may set the stage for damage to the brain that leads to cognitive issues in some Cushing’s patients, according to a study.
A history of unexplained deep vein thrombosis, or blood clots in the deep veins, in an obese woman was ultimately revealed as an undiagnosed case of Cushing’s disease, according to a case study. Venous thromboembolism, a group of conditions that includes deep vein thrombosis and pulmonary embolism (when blood…
Relacorilant, an oral treatment being developed by Corcept Therapeutics, appears to be safe and effective for controlling high blood pressure caused by hypercortisolism, or excess cortisol, in adults with endogenous Cushing’s syndrome, including Cushing’s disease. That’s according to GRACE (NCT03697109), an international Phase 3 clinical study…
In Cushing’s disease, an imaging technique that uses a radioactive tracer targeting the CXCR4 protein may help locate the tumor responsible for the condition, according to a Chinese study. The researchers also found that tumors with lower levels of CXCR4 were linked to higher recurrence rates. This technique combines…
A 20-year-old man developed exogenous, or therapy-related, Cushing’s syndrome after taking a high-dose steroid on his own for more than a year to treat autoimmune alopecia, a form of hair loss, according to a case report. The case “underscores the serious complications that can arise from steroid use,” the researchers…
Chronic pain and body image issues, not hormonal shifts, are the primary drivers of depression in people with Cushing’s syndrome, a new study finds. For many patients, the mental health toll of the rare disorder is shaped more by physical suffering and self-perception than by high cortisol levels. Therefore, treating…
A rare ectopic pituitary adenoma — a pituitary tumor growing outside its usual location — caused Cushing’s disease in a 52-year-old woman in Poland, according to a case report. The woman had developed Cushing’s symptoms, and laboratory tests confirmed a Cushing’s diagnosis. However, MRI scans did not reveal…
Genetic testing showed that a woman with a recurrent pituitary tumor causing Cushing’s disease had Lynch syndrome due to a mutation in the MSH6 gene — the second known case in which the syndrome may have triggered Cushing’s, according to a case report. Lynch syndrome is an inherited condition caused by…
Artificial intelligence (AI) tools may help predict which people with Cushing’s disease are likely to achieve remission after surgery, according to a new systematic review and meta-analysis. To evaluate how accurately AI can forecast remission outcomes, a team of researchers from the U.S., Iran, and Australia analyzed results from five…
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