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In Cushing’s disease, an imaging technique that uses a radioactive tracer targeting the CXCR4 protein may help locate the tumor responsible for the condition, according to a Chinese study. The researchers also found that tumors with lower levels of CXCR4 were linked to higher recurrence rates. This technique combines…

A 20-year-old man developed exogenous, or therapy-related, Cushing’s syndrome after taking a high-dose steroid on his own for more than a year to treat autoimmune alopecia, a form of hair loss, according to a case report. The case “underscores the serious complications that can arise from steroid use,” the researchers…

Chronic pain and body image issues, not hormonal shifts, are the primary drivers of depression in people with Cushing’s syndrome, a new study finds. For many patients, the mental health toll of the rare disorder is shaped more by physical suffering and self-perception than by high cortisol levels. Therefore, treating…

A rare ectopic pituitary adenoma — a pituitary tumor growing outside its usual location — caused Cushing’s disease in a 52-year-old woman in Poland, according to a case report. The woman had developed Cushing’s symptoms, and laboratory tests confirmed a Cushing’s diagnosis. However, MRI scans did not reveal…

Genetic testing showed that a woman with a recurrent pituitary tumor causing Cushing’s disease had Lynch syndrome due to a mutation in the MSH6 gene — the second known case in which the syndrome may have triggered Cushing’s, according to a case report. Lynch syndrome is an inherited condition caused by…

Artificial intelligence (AI) tools may help predict which people with Cushing’s disease are likely to achieve remission after surgery, according to a new systematic review and meta-analysis. To evaluate how accurately AI can forecast remission outcomes, a team of researchers from the U.S., Iran, and Australia analyzed results from five…

Stereotactic radiosurgery (SRS), a targeted form of radiation that precisely delivers high doses to tumors while sparing surrounding tissue, may be a safe and effective treatment to control hard-to-treat Cushing’s disease, according to a meta-analysis of published studies. SRS induced biochemical remission in about two-thirds of cases…

Bone complications are frequent in people with Cushing’s syndrome, including those with Cushing’s disease, but are not consistently assessed or treated across Europe, according to a large study. The findings, based on data from nearly 1,700 patients, showed that osteoporosis — a condition marked by fragile bones — and…

The blood-thinning medication rivaroxaban was safe and effective at preventing the formation of blood clots in deep veins or the lungs, known as venous thromboembolism (VTE), in people with adrenocorticotropic hormone (ACTH)-dependent Cushing’s syndrome, according to a recent study. The study demonstrated that the treatment prevented both new and recurrent…

Among adults with Cushing’s syndrome caused by tumors in both adrenal glands, surgery to remove the tumors led to the best cortisol control and the most favorable outcomes, according to a large international study. However, the risk of death and the rates of cardiovascular events were similar across different treatment…