Although acinic cell carcinoma — a cancer of the glands that produce saliva — is usually considered low risk, it can behave aggressively and cause Cushing’s syndrome, according to researchers who described such a case involving a 58-year-old man in Turkey. They added that if not recognized and treated…
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The U.S. Food and Drug Administration (FDA) has declined to approve relacorilant, an experimental oral therapy for patients with Cushing’s syndrome experiencing high blood pressure. In a complete response letter, the agency stated that current data do not yet conclusively show that the treatment’s benefits outweigh its risks. The…
Treatment with Isturisa (osilodrostat) normalized cortisol levels in most people with ectopic Cushing’s syndrome, including those with severe disease, according to real-world data from Spain. Normal cortisol levels were reached within a month of starting treatment in more than a third of patients (36%). “Therefore, [Isturisa] should be considered…
Asymptomatic Cushing’s syndrome alongside primary hyperaldosteronism, or PHA — a disorder marked by excessive secretion of the hormone aldosterone — was found to be the cause of persistent, hard-to-treat high blood pressure in a 57-year-old man, according to a new case study. The research team, from Iran, noted the “diagnostic…
A woman with persistent Cushing’s disease experienced two back-to-back pregnancies without significant problems for the mother or baby, a case study reported. “There are a limited number of cases of Cushing’s [disease] in pregnancy, therefore the best possible treatment is difficult to determine and should be individualised to the…
Isturisa (osilodrostat) can safely reduce, or even normalize, cortisol levels in people with various forms of endogenous Cushing’s syndrome that are not Cushing’s disease, according to data from a real-world study in France. The study, “Real-world osilodrostat effectiveness and safety in non-pituitary Cushing syndrome,” was…
Children with Cushing’s disease tend to have more total body fat than other children their age, even when their body mass index (BMI) is the same, a new study suggests. The study also found that detailed body-composition scans were better than BMI at predicting risks for issues such as…
Despite taking Isturisa (osilodrostat), a medication not recommended during pregnancy, a 38-year-old woman in Japan with recurrent Cushing’s disease carried a healthy baby through the first trimester, according to a newly published case report. After the pregnancy was discovered at 16 weeks, doctors immediately discontinued Isturisa. The woman’s…
When standard procedures fail, doctors may still be able to diagnose Cushing’s disease by sampling blood from veins near the pituitary gland using a catheter inserted through the neck — an alternative approach described in a new case report. The study, “Ultrasound-Guided Jugular Vein Access for…
A 43-year-old woman with Cushing’s disease developed an unusual sequence of psychiatric complications after rapid increases in her oral cortisol-lowering medication Isturisa (osilodrostat), a new case report from Japan shows. The woman first experienced a sudden worsening of her depression symptoms early in treatment, likely due to a transient rise…
Recent Posts
- Man’s aggressive salivary gland cancer triggers Cushing’s syndrome: Report
- FDA rejects relacorilant for Cushing’s-related high blood pressure
- Study supports Isturisa as first-line ectopic Cushing’s treatment
- After some scary complications, I finally gave birth to a baby girl
- Rare dual diagnosis explains man’s chronic high blood pressure: Report
- Woman with recurrent Cushing’s disease has 2 successful pregnancies
- Real-world study backs Isturisa for non-pituitary Cushing’s forms
- New research shows Cushing’s adds hidden fat BMI may overlook
- Isturisa exposure early in pregnancy may be less risky than thought
- Alternative neck access allows doctors to complete key test