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The noncancerous pituitary gland tumors that cause Cushing’s disease can rarely become cancerous, leading to rapidly progressing disease, a recent case report highlighted. Scientists reported on two middle-aged women with Cushing’s who underwent surgery and radiation therapy for their pituitary tumors. The tumors eventually recurred and spread, showing signs…

Care practices at a hospital in Taiwan align with those recommended by the Pituitary Society for patients with pituitary tumors, including those causing Cushing’s disease, a study found. The study found that practices at Taipei Veterans General Hospital fostered successful surgical interventions, a low risk of death, and a…

Unrestricted access to glucocorticoids, such as dexamethasone, and self-administration without prescription can lead to Cushing’s syndrome, a case series from Yemen showed. “The education of physicians, pharmacists, and patients is necessary to avoid this problem,” the researcher who conducted the study wrote. “Physicians should keep this in mind and question…

Children with Cushing’s disease whose pituitary tumors carry USP8 gene mutations tend to have larger, more invasive tumors and face a higher risk of persistent or recurrent disease after surgery, a study reports. While inherited mutations do not cause most pediatric cases, non-inherited mutations appear to influence tumor size…

The case of a 70-year-old U.S. man with ectopic Cushing’s syndrome caused by an unusual type of nasal tumor, called an olfactory neuroblastoma, was described in a report that, according to its author, “demonstrates the necessity of collaboration among endocrinology, otolaryngology, neurosurgery, radiology, and oncology teams in managing rare ACTH-secreting…

A positron emission tomography (PET)-based imaging technique is comparable to standard MRI in its ability to find small pituitary gland tumors related to Cushing’s disease, a study reports. While both techniques correctly identified the location of the tumors, called small pituitary neuroendocrine tumors (PitNETs), for most study participants, neither…

A 52‑year‑old woman who came to the hospital complaining of chest pain and difficulty breathing was found to have both lung cancer and Cushing’s syndrome. Researchers said the cancer caused the Cushing’s, a rare occurrence that shows the need for “a coordinated, multidisciplinary approach” to managing complex sets of symptoms.

Using precise, image-guided techniques for the delivery of radiotherapy can help control Cushing’s disease in cases where surgery to remove disease-causing tumors proves impossible or ineffective, a study reports. This type of stereotactic radiotherapy prevented further tumor growth in nearly 95% of participants and helped several reach normal levels…

Limiting the number of measurements in the low-dose overnight dexamethasone suppression test (oDST), which is commonly used to diagnose Cushing’s syndrome, does not affect the test’s performance, a study showed. A new protocol, called Reflex, performs additional tests only among people whose initial tests suggest the presence of Cushing’s.

Long-term use of topical corticosteroids for a genetic skin condition caused Cushing’s syndrome and adrenal insufficiency — low hormone production from the adrenal glands — in a 50-year-old woman, according to a case report. “This case highlights the risk of systemic complications from chronic topical corticosteroid use,” the researchers wrote.