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Analyzing the levels of a molecule called S1P — fully known as sphingosine-1-phosphate — in the tissue surrounding a pituitary gland tumor in Cushing’s disease patients can help determine the side of the gland on which the tumor is located. That’s according to a study that made use of…

A recent study supports the reliability of a diagnostic tool to distinguish adrenocorticotropic hormone (ACTH)-dependent forms of Cushing’s syndrome in people who have inconclusive imaging or biochemical test results. The procedure, called bilateral inferior petrosal sinus sampling (BIPSS), is able to accurately differentiate patients with Cushing’s disease from…

A five-week, low-calorie ketogenic diet led to weight loss and reduced blood pressure in people with Cushing’s disease in a small study. The diet also lowered blood levels of cholesterol and other fatty molecules, but did not alter cortisol levels, which are typically elevated in Cushing’s patients. Findings were…

Patients with persistent Cushing’s disease may benefit from combining Signifor (pasireotide) with cabergoline, according to the findings of a Phase 2 clinical trial. The results suggest the combo therapy “could be an effective long-term strategy for enhancing the control of CD [Cushing’s disease]” in patients who fail to respond or…

Corcept Therapeutics is expecting to earn nearly $500 million in revenue this year, which is due in large part to the increased recognition of Cushing’s syndrome, the company noted in a recent corporate update. Corcept, which markets Korlym (mifepristone) — a therapy approved to control high blood sugar in…

For a woman in her 60s in China, Cushing’s syndrome led to a myocardial infarction or heart attack, and to heart failure, according to a report on the rare case. The patient’s Cushing’s was secondary to an adrenocortical adenoma — a benign, or non-cancerous, tumor that formed in the…

More boys were diagnosed with Cushing’s disease before puberty than were girls, according to an examination of medical records of children and adolescent patients across Turkey. These findings contrast with observations made in adults, in whom women are diagnosed with Cushing’s far more often than men. The researchers noted,…

A 31-year-old woman exhibited unusual symptoms of Cushing’s disease following childbirth, but didn’t show some of the disease’s hallmark features, such as weight gain and fat accumulation. The woman’s atypical symptoms, which included psychosis and severe muscle weakness, were accompanied by a challenging clinical course that led ultimately…

For a man in Denmark, Cushing’s syndrome developed as a result of a medullary thyroid carcinoma — a tumor that formed in the thyroid gland in the neck and released corticotropin-releasing hormone (CRH), a hormone that triggers cortisol production. During the workup, however, results of inferior petrosal sinus sampling,…

People with Cushing’s disease have differences in brain activity that significantly associate with the severity of cognitive and mental health symptoms, implying such changes in brain activity may give rise to these symptoms. That’s according to the recent study “Dynamic functional connectivity changes associated with psychiatric traits and…