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Measuring cortisol in a small sample of saliva collected late at night may work just as well as the 24-hour urine test — which involves collecting urine passed during the day and night — for checking whether Cushing’s disease is in remission after radiotherapy, a study by U.S. researchers…

Individualized treatments helped two women and their babies avoid complications of Cushing’s syndrome during pregnancy, according to a case report. “Careful clinical observation during pregnancy and after delivery is necessary to initiate appropriate treatment,” the researchers wrote. Both cases were detailed in the study, “Diagnosis and Management…

Surgeons used ultrasound to successfully remove a pituitary tumor that was undetectable by MRI to cure a 55-year-old woman of Cushing’s disease, a case study reported. The case “suggests the potential utility of ultrasound in MRI-negative Cushing’s disease,” the researchers wrote. “It raises the possibility that even small pituitary…

A 30-year-old woman had a relapse of cyclic Cushing’s syndrome shortly after giving birth, according to a case report that researchers said underscores the importance of “long-term follow-up in patients with a high index of suspicion for cyclic [Cushing’s syndrome].” The study, “ACTH-dependent Cyclic Cushing Syndrome With…

Cognitive issues are most common in people with Cushing’s disease who have high cortisol levels in the morning, high blood sugar, and a high body mass index (BMI), a study shows. Based on these identified risk factors, researchers devised a mathematical model to help predict the risk of cognitive…

An adrenocorticotropic hormone (ACTH)-producing pheochromocytoma, a rare type of tumor in the adrenal gland, was the cause of Cushing’s syndrome in a 42-year-old woman, according to a case report in Mexico. The woman had no typical signs of Cushing’s, which delayed her diagnosis and made her “case particularly difficult…

The U.S. Food and Drug Administration (FDA) has approved Isturisa (osilodrostat) to treat adults with all forms of endogenous Cushing’s syndrome for whom surgery is not an option or has not been curative. This marks an expansion of the approved indication for Isturisa, which had previously been cleared only…

Most people with Cushing’s syndrome see their adrenal function recover after first-line surgery to remove disease-causing tumors, even though it may take several months or years, according to a study that also showed a younger age at diagnosis was linked to faster adrenal recovery. “The recovery rate of adrenal function…

Surgery for Cushing’s disease eases symptoms and improves heart health more effectively than medication, a new study by researchers at the University Hospital of Padova in Italy has found. However, some problems — specifically including obesity and high blood pressure — can still remain, especially if cortisol is not…

Two women with Cushing’s disease successfully used the cortisol-lowering medication metyrapone during their pregnancy, a case study shows. “Metyrapone represents a viable option for managing [Cushing’s disease] throughout pregnancy when surgical intervention is contraindicated or declined, although careful monitoring and dose optimization are essential,” the researchers wrote. The cases…