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Changes in gut bacteria may underlie the development of mental health problems in people with Cushing’s disease, a study found. The study, “The gut microbiome in patients with Cushing’s disease affects depression- and anxiety-like behavior in mice,” was published in Microbiome. Cushing’s disease is characterized by…

A 70-year-old woman in the U.S. with Cushing’s syndrome due to advanced adrenal gland cancer who was effectively managed with Isturisa (osilodrostat) was the subject of a report by researchers. After the woman developed adrenal insufficiency, which is when the adrenal glands become unable to produce sufficient amounts of…

A woman developed therapy-related Cushing’s syndrome after prolonged treatment with a glucocorticoid for osteoarthritis, which is marked by joint damage and degeneration, a case study reports. As a result, the woman developed adrenal insufficiency and was misdiagnosed with perimenopause. In adrenal insufficiency, the adrenal glands become unable to produce sufficient…

All patients who completed a Phase 2 clinical trial of clofutriben, an oral small molecule that Sparrow Pharmaceuticals is developing for endogenous Cushing’s syndrome, chose to continue on the experimental treatment as part of a planned open-label extension. Overall, the results of the trial, dubbed RESCUE, showed promise, Sparrow…

A 75-year-old woman with Cushing’s disease who was first seen with marked weight loss and low blood levels of potassium, or hypokalemia, was described by researchers as an unusual example of the condition, one otherwise resembling ectopic Cushing’s syndrome. “This case highlights the need to entertain a broad differential…

Researchers in Japan have reported what they say is the third case of Cushing’s disease in a woman pregnant with twins. The disease was mostly resolved with surgery after she gave birth. While there were signs suggestive of Cushing’s disease during her pregnancy, the woman was only formally diagnosed…

Surgical removal of one cancerous adrenal gland resulted in disease remission after six months in nearly half of people with Cushing’s syndrome due to tumors in both adrenal glands — a condition known as primary bilateral macronodular adrenal hyperplasia, or PBMAH. That’s according to data from a study in China…

Doctors in England missed signs of Cushing’s syndrome in a 26-year-old woman with gestational diabetes and high blood pressure, a case researchers said highlights the need for heightened awareness and vigilance, particularly in pregnant women with those conditions. “The diagnosis of [Cushing’s syndrome] in pregnancy is not straightforward due to…

High levels of cortisol in the bloodstream of people with Cushing’s syndrome were directly linked to significant metabolic abnormalities leading to the buildup of fat deposits in the liver, according to a new study from researchers in China. The researchers noted that liver fat accumulation increases a person’s risk of…

A 46-year-old man with Cushing’s disease in the U.S. lacked many of the typical symptoms due to impairments in the activity of an enzyme called 11 beta-hydroxysteroid dehydrogenase type 1 (HSD-1), according to a recent case report. HSD-1 is needed for cells to convert cortisone, an inactive form of…