A diagnostic test using an artificial form of the naturally occurring hormone desmopressin could be a good alternative to the standard test used to diagnose Cushing’s disease in children and adolescents, according to a study. Researchers found that the accuracy of the desmopressin stimulation test (DDAVP) was comparable to…
News
Although acinic cell carcinoma — a cancer of the glands that produce saliva — is usually considered low risk, it can behave aggressively and cause Cushing’s syndrome, according to researchers who described such a case involving a 58-year-old man in Turkey. They added that if not recognized and treated…
The U.S. Food and Drug Administration (FDA) has declined to approve relacorilant, an experimental oral therapy for patients with Cushing’s syndrome experiencing high blood pressure. In a complete response letter, the agency stated that current data do not yet conclusively show that the treatment’s benefits outweigh its risks. The…
Treatment with Isturisa (osilodrostat) normalized cortisol levels in most people with ectopic Cushing’s syndrome, including those with severe disease, according to real-world data from Spain. Normal cortisol levels were reached within a month of starting treatment in more than a third of patients (36%). “Therefore, [Isturisa] should be considered…
Asymptomatic Cushing’s syndrome alongside primary hyperaldosteronism, or PHA — a disorder marked by excessive secretion of the hormone aldosterone — was found to be the cause of persistent, hard-to-treat high blood pressure in a 57-year-old man, according to a new case study. The research team, from Iran, noted the “diagnostic…
A woman with persistent Cushing’s disease experienced two back-to-back pregnancies without significant problems for the mother or baby, a case study reported. “There are a limited number of cases of Cushing’s [disease] in pregnancy, therefore the best possible treatment is difficult to determine and should be individualised to the…
Isturisa (osilodrostat) can safely reduce, or even normalize, cortisol levels in people with various forms of endogenous Cushing’s syndrome that are not Cushing’s disease, according to data from a real-world study in France. The study, “Real-world osilodrostat effectiveness and safety in non-pituitary Cushing syndrome,” was…
Children with Cushing’s disease tend to have more total body fat than other children their age, even when their body mass index (BMI) is the same, a new study suggests. The study also found that detailed body-composition scans were better than BMI at predicting risks for issues such as…
Despite taking Isturisa (osilodrostat), a medication not recommended during pregnancy, a 38-year-old woman in Japan with recurrent Cushing’s disease carried a healthy baby through the first trimester, according to a newly published case report. After the pregnancy was discovered at 16 weeks, doctors immediately discontinued Isturisa. The woman’s…
When standard procedures fail, doctors may still be able to diagnose Cushing’s disease by sampling blood from veins near the pituitary gland using a catheter inserted through the neck — an alternative approach described in a new case report. The study, “Ultrasound-Guided Jugular Vein Access for…
Recent Posts
- Targeted radiation therapy offers hope for tough Cushing’s cases
- Bone problems common in Cushing’s, but care varies across Europe: Study
- How Cushing’s disease has made me a better parent
- Blood thinner rivaroxaban prevents clots in ACTH-dependent Cushing’s
- Surgery offers best cortisol control for adrenal Cushing’s syndrome
- Turning negatives into positives keeps me out of the ‘why me’ pit
- Common Cushing’s test may miss aggressive tumors in some patients
- Weak bones, fractures prevalent in Cushing’s syndrome: Analysis
- We’re preparing to finally bring our newborn daughter home
- Surgery brings Cushing’s remission to 60% of patients over 20 years: Study