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Sterotherapeutics has announced the launch of a Phase 2 clinical trial to test its experimental therapy ST-002 in people with Cushing’s syndrome. “This trial represents a significant step forward in our mission to develop transformative therapies for unmet medical needs,” Manohar Katakam, PhD, CEO of Sterotherapeutics, said in…

In rare cases, Cushing’s syndrome can be caused by tumors that are simultaneously producing two signaling molecules called adrenocorticotropic hormone (ACTH) and corticotropin-releasing hormone (CRH). Diagnosing Cushing’s in these cases can be complex, leading to delays in treatment and worse outcomes for patients, according to a new report. “Studies…

One person out of five with Cushing’s syndrome in Israel has higher than normal numbers of white blood cells that drop within two years after surgery, but may still remain higher than the general population, a study finds.  Patients with Cushing’s disease, a specific type of Cushing’s syndrome…

A 71-year-old man with Cushing’s disease developed avascular necrosis in the hips and shoulders, a condition in which bone tissue dies due to lack of blood supply, a U.S. case study reports. His Cushing’s symptoms, including avascular necrosis in the hips, were successfully managed with surgery to remove the…

Treatment with mesenchymal stem cells, a type of adult stem cell, was shown to reduce the levels of low-density lipoprotein (LDL) cholesterol — known as bad cholesterol — in a mouse model of exogenous Cushing’s syndrome, according to a study conducted in South Korea. The researchers noted that exogenous Cushing’s,…

A young woman who developed Cushing’s syndrome three years after being diagnosed with a metastatic neuroendocrine tumor saw her cortisol levels decrease and Cushing’s-related symptoms ease after being treated with Isturisa (osilodrostat). The woman, 27, was started on hydrocortisone when here cortisol levels fell to lower than normal values,…

Differences in the levels of hormones made by the adrenal glands, which sit atop the kidneys, may explain why bone density is less affected in women with Cushing’s disease than in female patients with other forms of Cushing’s syndrome, a new study from researchers in China reports. Their results…

People with Cushing’s syndrome, including those with Cushing’s disease, are at a higher risk of developing cataracts, causing blurry vision, than the general population, a study from Israel finds. Cataracts, which occur when the eye’s lens becomes cloudy, also developed nearly three years earlier than in the general population,…

Long-term treatment with Isturisa (osilodrostat) may help lower blood pressure, and blood sugar, levels in people with Cushing’s disease who have high blood pressure, also known as hypertension, or diabetes, according to a new analysis. Use of the approved medication for up to 1.4 years helped to ease…

People with Cushing’s disease may have higher levels of cortisol and more severe symptoms than those with other forms of Cushing’s, according to a recent study in Turkey. “The severity of disease symptoms worsens with increasing cortisol levels,” researchers wrote. The study, “Metabolic, hormonal profiles and comorbidities in…