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Two women with Cushing’s disease successfully used the cortisol-lowering medication metyrapone during their pregnancy, a case study shows. “Metyrapone represents a viable option for managing [Cushing’s disease] throughout pregnancy when surgical intervention is contraindicated or declined, although careful monitoring and dose optimization are essential,” the researchers wrote. The cases…

Cushing’s Awareness Day, which marks the birthday on April 8 of Harvey Cushing, becomes Cushing’s Awareness Month this year thanks to the efforts of the Cushing’s Support & Research Foundation (CSRF), which hopes to shine some light throughout the month on this group of diseases caused by excessive exposure…

Despite the known risk of osteoporosis among people with Cushing’s syndrome, only about 6% underwent bone mineral density (BMD) analysis within two years of diagnosis, a study using an insurance database shows. BMD testing assesses levels of calcium and other minerals in bone. Osteoporosis, which is characterized by…

A woman in her early 30s who developed severe ectopic Cushing’s syndrome due to a small thymus tumor was effectively managed with medications to reduce cortisol levels followed by surgery, according to a case report from Poland. After the initial surgery, the patient experienced two recurrences of Cushing’s within seven…

Endoscopic transsphenoidal surgery, which allows a surgeon to gain access to the brain through the nose to remove a pituitary tumor causing Cushing’s disease, was found to be safe and effective for bringing about remission in children, with few complications. While this surgery is usually done in adults with…

Treatment with Signifor (pasireotide) normalized urinary cortisol levels in about half of adults with Cushing’s disease, regardless of their gender, a small real-world study suggests. Because treatment response was associated with the absence of diabetes before treatment, researchers suggest proper blood sugar management in patients planning to start…

A woman in Switzerland with metastatic lung cancer who developed thin skin and was later diagnosed with Cushing’s syndrome was the subject of a repoort by researchers. Metastatic cancer occurs when the disease has spread from its original site to other parts of the body. In this case, Cushing’s was…

An 8-year-old girl was diagnosed with primary pigmented nodular adrenocortical disease (PPNAD), a rare genetic disorder that can cause Cushing’s syndrome, a case study reports. Hers was the first reported case of PPNAD caused by a duplication in the PRKACA gene. according to the researchers. The girl’s case was described in…

  A clinical trial aims to assess the prevalence of Cushing’s syndrome in adults with hard-to-treat high blood pressure. The trial, called MOMENTUM (NCT06829537), plans to recruit 1,000 adults with hypertension (high blood pressure) that remains uncontrolled despite the use of at least three different types of medications designed…

A young woman with Cushing’s disease and acromegaly — marked by the abnormal growth of certain body parts due to pituitary gland dysfunction — saw her symptoms ease after undergoing surgery to remove a large hormone-producing tumor that caused both rare conditions, a study from Bangladesh reported. “The…