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A 71-year-old woman developed cyclic Cushing’s syndrome, where periods of hypercortisolism alternate with periods of normal or low cortisol levels, as the result of a pheochromocytoma, a rare type of tumor that forms in the adrenal glands atop the kidneys. Cushing’s syndrome is due to high cortisol levels, or…

Severe hypokalemia, or extremely low blood potassium levels, may be the first manifestation of Cushing’s disease, as illustrated in a recent case report. The study described the case of a 48-year-old man with Cushing’s disease who had surgery to remove a pituitary macroadenoma, or a large pituitary tumor, but…

Lundbeck has launched a Phase 2 clinical trial to assess the efficacy, safety, and tolerability of Lu AG13909, a potential first-in-class treatment for Cushing’s disease. “We are pleased to advance this new approach to potentially treating unmet needs in Cushing’s disease, a condition that, when uncontrolled, is debilitating…

Lower urinary cortisol levels at the start of treatment with Recorlev (levoketoconazole) are associated with higher rates of cortisol normalization among people with endogenous Cushing’s syndrome, according to new analyses from a Phase 3 clinical trial. Patients with lower starting cortisol levels also require lower maintenance doses of Recorlev…

Sparrow Pharmaceuticals’ oral small molecule SPI-62, now being called clofutriben, can lower the levels of free cortisol in the urine of people with Cushing’s syndrome caused by a tumor outside the adrenal glands, including those with Cushing’s disease. Unlike other cortisol-lowering medications, which require careful dosing to prevent…

Daily meditation with the help of headband that tracks brain activity and serves as a personal meditation coach may help people with Cushing’s syndrome have less pain and a better experience while recovering from surgery. That’s according to new research presented at the Endocrine Society Annual Meeting (ENDO 2024) in…

CRN04894, now being called atumelnant, quickly lowered urine cortisol levels in five people with ACTH-dependent Cushing’s syndrome taking part in a clinical trial, according to interim study findings. The open-label Phase 1b/2a trial (NCT05804669), which is being conducted at the National Institutes of Health (NIH) in Maryland, still…

People with Cushing’s syndrome, including those with Cushing’s disease, appear to have more heart issues — like poorer heart function and larger ventricles, which are the heart’s lower chambers — compared with other patients with similar cardiovascular risk factors, a study using MRI imaging has found. The heart issues…

Among people with endogenous Cushing’s syndrome whose high blood pressure, or hypertension, dropped after five months on relacorilant, that response was maintained when the patients continued treatment for an additional period of three months. That’s according to new data from the randomized withdrawal phase of the Phase 3…

Blood levels of cortisol or adrenocorticotropic hormone (ACTH) measured one day after pituitary tumor removal surgery independently predicted Cushing’s disease remission after one year, according to a real-world study. Post-surgical remission rates were higher among adults after a first surgery compared with those seen for patients who underwent a second…