News

About 80% of people with recurrent Cushing’s disease who underwent a second surgery to remove tumors from the brain’s pituitary gland achieved remission, according to a real-world study. These findings show that repeat surgery “emerges as a reliable and safe treatment modality for residual or recurrent Cushing’s disease, offering…

People with Cushing’s syndrome, marked by high levels of cortisol, had altered red blood cell profiles at diagnosis, according to a study of nearly 400 patients and 2,000 matched controls. Among those with Cushing’s disease, a subtype of the syndrome, remission was more likely to occur in people with…

People with Cushing’s syndrome have an increased risk of venous thromboembolism (VTE), that is, dangerous blood clots that obstruct the normal flow of blood through veins, but most treatment centers don’t have standard procedures for reducing VTE risk in Cushing’s patients, a study indicates. “A specific thromboprophylaxis protocol for patients…

The prolonged use of an injectable medication containing an anti-inflammatory corticosteroid to treat abdominal pain led to the onset of Cushing’s syndrome in a 62-year-old woman, as described in a case reported by a team in Florida. The woman was being treated for pain associated with chronic inflammation in the…

The presence of somatic mutations in the USP8 gene, found in up to half of people with Cushing’s disease, appears to have no impact on how well patients fare after undergoing surgery to remove a disease-causing pituitary tumor, a study has found. However, patients with USP8 mutations — all…

A technique called trabecular bone score, or TBS, may be better at assessing bone damage and loss than bone mineral density, the current gold standard, in successfully treated patients with Cushing’s disease, according to a recent study. High cortisol levels characterize Cushing’s, and they are known to increase the…

A 44-year-old woman was found to have a hormone-producing tumor in her left adrenal gland, which produced and released both cortisol and testosterone, leading to the onset of Cushing’s syndrome. The high levels of testosterone produced and released by the tumor also caused her to develop virilization, a condition in…

For people who undergo surgery to treat Cushing’s disease or other forms of endogenous Cushing’s syndrome, replacement treatment with glucocorticoids may not be necessary immediately before or after the procedure, a study suggests. Rather, findings favored “withholding perioperative glucocorticoids until the first postoperative day (or even longer),” the researchers…

Among people with Cushing’s syndrome who enter into remission, women appear to be more likely than men to develop certain new conditions, including autoimmune disorders, within one year. That’s according to the findings of a systematic literature review done by researchers who reported on the case of a 42-year-old man…

About five months of treatment with relacorilant significantly reduced both high blood pressure and high blood sugar levels in people with endogenous Cushing’s syndrome, according to data from a Phase 3 trial. Relacorilant also was found to be generally safe and well tolerated, and to be able to significantly…