The first participant has been dosed in a Phase 2 clinical trial testing ST-002 in people with Cushing’s syndrome and high blood sugar levels. “ST-002 has the potential to change the treatment landscape for patients who currently have limited therapeutic options,” Manohar Katakam, PhD, CEO of treatment developer Sterotherapeutics,…
News
Early screening and treatment for possible underlying causes of obesity, such as Cushing’s disease, before a weight-loss procedure called bariatric surgery may help prevent mismanaging the condition and improve patient outcomes. That’s according to a report that described the case of a man in Iraq who developed complications and…
Sequential treatment with ketoconazole to lower cortisol levels and octreotide to help keep cortisol under control may be effective as a treatment for a subset of people with mild Cushing’s disease, according to a study from the Netherlands. Two of the three patients who responded to treatment, reflected…
Surgery to remove pituitary tumors, the first-line treatment for Cushing’s disease, can increase the risk of venous thromboembolism (VTE), or blood clot formation in veins, especially within a week of the procedure, according to a new study. Identified risk factors for post-surgical VTE include older age, high blood pressure,…
Low-dose aspirin, an antiplatelet agent used to reduce blood clotting, may be better than enoxaparin, the current gold standard, at preventing thromboses in people with Cushing’s syndrome, a U.S. study found. Compared with those on enoxaparin, a form of low-molecular weight heparin (LMWH), patients who took low-dose aspirin had a…
Ectopic Cushing’s syndrome can have different outcomes depending on tumor type, with about 8 in 10 people with lung tumors and 4 in 10 with pancreatic tumors remaining alive five years after diagnosis, according to a meta-analysis study by researchers in Sweden. Patients lived longer when the tumor could…
A test that uses the hormone-release stimulant desmopressin to trace the source of excess adrenocorticotropic hormone (ACTH) helped correctly diagnose Cushing’s disease in four children, but was less reliable in precisely locating the disease-causing tumor, according to a report from Iran. Desmopressin could be a “cost-effective alternative” to…
An imaging technique developed by scientists in India may help clinicians accurately identify tumors associated with Cushing’s disease, including in cases that are difficult to diagnose with other methods, a study reports. This new method uses a novel form of positron emission tomography (PET) imaging alongside CT scans to…
A U.S. case study describes woman in remission from Cushing’s disease who later developed a different form of Cushing’s syndrome, a rare occurrence that researchers said suggests the need for recognizing that this may happen and adopting individualized treatment approaches. The woman was initially diagnosed with Cushing’s disease, a…
People with adrenal Cushing’s syndrome who were diagnosed in the 2000s often had the condition identified incidentally — but also experience fewer symptoms specific to Cushing’s compared with individuals receiving a diagnosis in previous decades, a study in Japan has found. However, the prevalence of Cushing’s-related complications, including cardiovascular events…
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