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Older Cushing’s disease patients less frequently present classical symptoms of the disease, and have more coexistent conditions and larger tumors than those who develop the disease at a younger age. That’s according to a study that analyzed patients at several sites in the U.S. who underwent surgery to…

A rare and aggressive form of thyroid cancer caused Cushing’s syndrome in a man in his 30s, according to a case report. “This case underscores the complexity of diagnosing and managing ectopic Cushing’s syndrome, particularly when it is secondary to a rare malignancy,” researchers wrote. The case report, “…

Corcept Therapeutics has asked the U.S. Food and Drug Administration (FDA) to approve relacorilant for people with endogenous Cushing’s syndrome. “Relacorilant’s combination of efficacy and safety give it the potential to become the standard of care for the medical treatment of patients with hypercortisolism,” Joseph Belanoff, MD, CEO…

Long-term treatment with relacorilant led to a sustained decrease in blood pressure, blood sugar levels, and body weight in people with Cushing’s syndrome, new data from an extension study shows. The extension study (NCT03604198) is assessing relacorilant’s long-term safety and efficacy in 116 people with Cushing’s who completed…

Korlym (mifepristone) significantly reduced levels of hemoglobin A1c, a marker that reflects blood sugar levels over the previous months, in people with Cushing’s syndrome and difficult-to-control type 2 diabetes. That’s according to new data from a Phase 4 clinical trial, CATALYST (NCT05772169), which screened 1,057 patients with difficult-to-control…

An elderly woman developed Cushing’s syndrome after a year of using a so-called magic mouthwash — a rinse containing a potent topical corticosteroid — to treat an inflammatory disease affecting the mouth, according to a case study from Australia. About two months after stopping use of the steroid mouthwash,…

Patients being treated with Isturisa (osilodrostat) for Cushing’s disease see better long-term clinical outcomes when both late-night salivary cortisol and mean urinary free cortisol returned to normal levels, instead of just one or neither of those measures. Drawing on data from two Phase 3 clinical studies, LINC-3…

A protein called ACBP mediates the relationship between elevated levels of cortisol, the hallmark feature of Cushing’s syndrome, and the development of associated symptoms, according to a mouse study led by researchers in France. Using several methods to suppress ACBP activity, the researchers abolished Cushing’s signs in the mice —…

People with Cushing’s syndrome have soft bones, even after being in remission for a long time, a study reported. Despite having comparable bone mineral density, a standard measure of bone health based on its mineral content, Cushing’s patients in remission scored significantly lower on the material strength index (BMSi), an…

The diagnosis of a 33-year-old woman with Cushing’s disease was delayed due to the presence of mild, nonspecific symptoms, a tumor in the adrenal glands, and normal blood levels of the adrenocorticotropic hormone (ACTH), according to a new case study. The woman’s move from Canada to the U.K. also…