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A protein called ACBP mediates the relationship between elevated levels of cortisol, the hallmark feature of Cushing’s syndrome, and the development of associated symptoms, according to a mouse study led by researchers in France. Using several methods to suppress ACBP activity, the researchers abolished Cushing’s signs in the mice —…

People with Cushing’s syndrome have soft bones, even after being in remission for a long time, a study reported. Despite having comparable bone mineral density, a standard measure of bone health based on its mineral content, Cushing’s patients in remission scored significantly lower on the material strength index (BMSi), an…

The diagnosis of a 33-year-old woman with Cushing’s disease was delayed due to the presence of mild, nonspecific symptoms, a tumor in the adrenal glands, and normal blood levels of the adrenocorticotropic hormone (ACTH), according to a new case study. The woman’s move from Canada to the U.K. also…

Ectopic Cushing’s syndrome in a 10-year-old girl that was caused by a thymus tumor was effectively managed with ketoconazole and surgery to remove the thymus, according to a case report from the Czech Republic. “This case presents some unique challenges related to the diagnosis, management, and treatment of thymic…

People with Cushing’s syndrome are at a high risk of glaucoma — an eye condition in which the optic nerve that connects the eye and brain becomes damaged, potentially leading to vision loss — according to a new study that found the risk for Cushing’s patients is 74% greater than…

People with Cushing’s disease frequently experience cognitive and psychiatric complications, often persisting after surgery to remove the disease-driving tumor, a review study noted. That could be because high cortisol levels during active phases of Cushing’s disease can cause physical changes in brain structure that persist after cortisol levels are…

Changes in gut bacteria may underlie the development of mental health problems in people with Cushing’s disease, a study found. The study, “The gut microbiome in patients with Cushing’s disease affects depression- and anxiety-like behavior in mice,” was published in Microbiome. Cushing’s disease is characterized by…

A 70-year-old woman in the U.S. with Cushing’s syndrome due to advanced adrenal gland cancer who was effectively managed with Isturisa (osilodrostat) was the subject of a report by researchers. After the woman developed adrenal insufficiency, which is when the adrenal glands become unable to produce sufficient amounts of…

A woman developed therapy-related Cushing’s syndrome after prolonged treatment with a glucocorticoid for osteoarthritis, which is marked by joint damage and degeneration, a case study reports. As a result, the woman developed adrenal insufficiency and was misdiagnosed with perimenopause. In adrenal insufficiency, the adrenal glands become unable to produce sufficient…

All patients who completed a Phase 2 clinical trial of clofutriben, an oral small molecule that Sparrow Pharmaceuticals is developing for endogenous Cushing’s syndrome, chose to continue on the experimental treatment as part of a planned open-label extension. Overall, the results of the trial, dubbed RESCUE, showed promise, Sparrow…