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CRN04894, now being called atumelnant, quickly lowered urine cortisol levels in five people with ACTH-dependent Cushing’s syndrome taking part in a clinical trial, according to interim study findings. The open-label Phase 1b/2a trial (NCT05804669), which is being conducted at the National Institutes of Health (NIH) in Maryland, still…

People with Cushing’s syndrome, including those with Cushing’s disease, appear to have more heart issues — like poorer heart function and larger ventricles, which are the heart’s lower chambers — compared with other patients with similar cardiovascular risk factors, a study using MRI imaging has found. The heart issues…

Among people with endogenous Cushing’s syndrome whose high blood pressure, or hypertension, dropped after five months on relacorilant, that response was maintained when the patients continued treatment for an additional period of three months. That’s according to new data from the randomized withdrawal phase of the Phase 3…

Blood levels of cortisol or adrenocorticotropic hormone (ACTH) measured one day after pituitary tumor removal surgery independently predicted Cushing’s disease remission after one year, according to a real-world study. Post-surgical remission rates were higher among adults after a first surgery compared with those seen for patients who underwent a second…

About 80% of people with recurrent Cushing’s disease who underwent a second surgery to remove tumors from the brain’s pituitary gland achieved remission, according to a real-world study. These findings show that repeat surgery “emerges as a reliable and safe treatment modality for residual or recurrent Cushing’s disease, offering…

People with Cushing’s syndrome, marked by high levels of cortisol, had altered red blood cell profiles at diagnosis, according to a study of nearly 400 patients and 2,000 matched controls. Among those with Cushing’s disease, a subtype of the syndrome, remission was more likely to occur in people with…

People with Cushing’s syndrome have an increased risk of venous thromboembolism (VTE), that is, dangerous blood clots that obstruct the normal flow of blood through veins, but most treatment centers don’t have standard procedures for reducing VTE risk in Cushing’s patients, a study indicates. “A specific thromboprophylaxis protocol for patients…

The prolonged use of an injectable medication containing an anti-inflammatory corticosteroid to treat abdominal pain led to the onset of Cushing’s syndrome in a 62-year-old woman, as described in a case reported by a team in Florida. The woman was being treated for pain associated with chronic inflammation in the…

The presence of somatic mutations in the USP8 gene, found in up to half of people with Cushing’s disease, appears to have no impact on how well patients fare after undergoing surgery to remove a disease-causing pituitary tumor, a study has found. However, patients with USP8 mutations — all…

A technique called trabecular bone score, or TBS, may be better at assessing bone damage and loss than bone mineral density, the current gold standard, in successfully treated patients with Cushing’s disease, according to a recent study. High cortisol levels characterize Cushing’s, and they are known to increase the…