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A test that uses the hormone-release stimulant desmopressin to trace the source of excess adrenocorticotropic hormone (ACTH) helped correctly diagnose Cushing’s disease in four children, but was less reliable in precisely locating the disease-causing tumor, according to a report from Iran. Desmopressin could be a “cost-effective alternative” to…

An imaging technique developed by scientists in India may help clinicians accurately identify tumors associated with Cushing’s disease, including in cases that are difficult to diagnose with other methods, a study reports. This new method uses a novel form of positron emission tomography (PET) imaging alongside CT scans to…

A U.S. case study describes woman in remission from Cushing’s disease who later developed a different form of Cushing’s syndrome, a rare occurrence that researchers said suggests the need for recognizing that this may happen and adopting individualized treatment approaches. The woman was initially diagnosed with Cushing’s disease, a…

People with adrenal Cushing’s syndrome who were diagnosed in the 2000s often had the condition identified incidentally — but also experience fewer symptoms specific to Cushing’s compared with individuals receiving a diagnosis in previous decades, a study in Japan has found. However, the prevalence of Cushing’s-related complications, including cardiovascular events…

Treatment with Isturisa (osilodrostat) was found to be effective for reducing cortisol levels in people with Cushing’s disease and other forms of Cushing’s syndrome, according to data from a real-world study. The study, “Osilodrostat Treatment of Cushing Syndrome in Real-World Clinical Practice: Findings From the…

Measuring cortisol in a small sample of saliva collected late at night may work just as well as the 24-hour urine test — which involves collecting urine passed during the day and night — for checking whether Cushing’s disease is in remission after radiotherapy, a study by U.S. researchers…

Individualized treatments helped two women and their babies avoid complications of Cushing’s syndrome during pregnancy, according to a case report. “Careful clinical observation during pregnancy and after delivery is necessary to initiate appropriate treatment,” the researchers wrote. Both cases were detailed in the study, “Diagnosis and Management…

Surgeons used ultrasound to successfully remove a pituitary tumor that was undetectable by MRI to cure a 55-year-old woman of Cushing’s disease, a case study reported. The case “suggests the potential utility of ultrasound in MRI-negative Cushing’s disease,” the researchers wrote. “It raises the possibility that even small pituitary…

A 30-year-old woman had a relapse of cyclic Cushing’s syndrome shortly after giving birth, according to a case report that researchers said underscores the importance of “long-term follow-up in patients with a high index of suspicion for cyclic [Cushing’s syndrome].” The study, “ACTH-dependent Cyclic Cushing Syndrome With…

Cognitive issues are most common in people with Cushing’s disease who have high cortisol levels in the morning, high blood sugar, and a high body mass index (BMI), a study shows. Based on these identified risk factors, researchers devised a mathematical model to help predict the risk of cognitive…